Rebamipide 100 mg. Price, instructions for use, reviews

Rebamipide is effective gastroprotective agent with pronounced properties, which is prescribed to patients when diagnosing pathologies of the digestive tract at different stages.

The medication helps to restore the affected areas and reduces the likelihood of their enlargement. Usually, patients are prescribed a dosage of 100 mg, but this may differ depending on the indication. The cost of the drug is high, but justified, since the effectiveness has been proven by the opinion of many patients, left after undergoing therapy.

Composition and form of release

The drug can be found in pharmacies in the form of film-coated tablets for oral use. They are small in size and round, biconvex, white or nearly white in color.

The tablets are placed in plates of a standard size, 10 pieces each. In a small cardboard package there are 3 plates, as well as a description that indicates the nuances of using the medication, possible contraindications and complications.

The composition of the drug includes the component rebamipide, which provides the main therapeutic effect on the patient's body.

The tablets contain excipients:

• Microcrystalline cellulose.
• Povidone.
• Talc.
• Starch.
• Magnesium stearate.
• Polysorbate.
• Titanium dioxide.

The amount of the basic substance in the tablet is 100 mg.

Terms of sale, prices

Rebamipide 100 mg is dispensed in pharmacies in different regions after presentation of a prescription form from a doctor. The price of the product ranges from 430-500 rubles.

The cost may differ depending on a specific pharmacy, region of distribution.

Pharmacological properties

The drug has gastroprotective properties, helps to restore lesions on the mucous membranes of the stomach. The medication is used as an independent method of therapy or in combination with other drugs to increase the effectiveness of treatment.

The tool additionally protects tissues from the negative effects of food, drinks and some drugs. The complex effect on tissues prevents the development of complications, improves the general condition of tissues and metabolism in their cells.

Pharmacodynamics and pharmacokinetics

The action of the drug is noted quite quickly after oral administration of the tablets in a single dosage. The active ingredient slightly changes the composition of gastric juice, reduces the concentration of components in it that provoke damage to the mucous membranes against the background of certain pathologies, nutritional characteristics.

The medication helps prevent the progression of diseases, reduces the likelihood of complications from other organs.

Another action of the remedy is noted:

• Reduces the negative effects of ethanol, acids, alkalis on the mucous membranes of the stomach. There is a decrease in negative reactions when using funds based on acetylsalicylic acid.
• The tool helps to restore the affected areas, even with an increase in their area, but does not completely eliminate the symptoms of pathology if it proceeds in an acute form.
• The drug not only stimulates the restoration of stomach tissues, but also improves metabolic processes in the mucous membrane by stimulating the flow of blood and nutritional components to it. As a result, the likelihood of the occurrence of disorders associated with improper blood circulation is reduced.
• It activates the barrier function of the stomach, which has a positive effect on the patient's condition.
• Stimulates cell division of the mucous membrane, which speeds up tissue repair.
• Prevents the growth of bacteria in the digestive tract. This is especially important for patients with gastritis provoked by the bacterium Helicobacter pylori.

The drug also weakens the negative effect on the mucous membranes of the stomach of non-steroidal anti-inflammatory drugs.

After the tablet has penetrated inside, its dissolution occurs quickly, and the active ingredient enters the systemic circulation. Approximately 2 hours after oral administration of the drug, its maximum concentration in the blood is noted. The bioavailability of the main substance is high, which ensures efficiency.

The binding of the component to plasma proteins occurs approximately at 96-98%. After the processing of the ingredients in the liver, they are excreted through the kidneys, mainly unchanged. Only 10% of the total amount of the drug is excreted by the kidneys. The rest is evacuated using the digestive system.

The accumulation of ingredients in the blood and tissues does not occur, which is considered an advantage over other drugs, since it does not provoke an overdose.

Indications for use

Rebamipide 100 mg (the price of the drug is high) is prescribed for patients with various diseases affecting the tissues of the stomach and duodenum.

The main indications for use:

• Ulcerative and erosive lesions of the stomach and duodenum. The pharmacological agent can be used in the acute and subacute stages to improve the condition and prevent the development of complications.
• Gastritis at various pathological stages. Usually, tablets are prescribed when the level of hydrochloric acid increases, when its intensive production leads to damage to the gastric mucosa.
• Erosive form of gastritis in patients who previously suffered from pathologies of the digestive system.

  

The drug is often prescribed in combination with non-steroidal anti-inflammatory drugs to prevent the development of negative reactions from the stomach and intestines. As part of the combined treatment, the medication is used to increase its effectiveness.

Contraindications

The drug is not used when diagnosing intolerance to the components of the composition or a tendency to such reactions in history.

Other barriers to treatment include:

• The period of gestation and breastfeeding. There is no data on the safety of the drug for patients during these periods, therefore, if necessary, another drug is selected.
• The patient's age is up to 18 years. The drug can provoke complications in children and adolescents, so it is better to use safer means.
• Severe heart failure.
• An uncontrolled form of arterial hypertension, in which it is difficult to control the numbers with the help of antihypertensive medications.
• Internal bleeding as a result of perforation of the wall of the stomach or intestines.
• A state of shock against the background of injuries, pathologies of the heart, brain, internal organs.
• Acute poisoning with vomiting and upset stools.
• Dehydration of the body.
• Liver failure and severe hepatitis, cirrhosis.
• Lack of kidney function, infectious pathology of the paired organ in acute form.

With caution, the medication is used in the treatment of elderly patients, which is associated with the presence of chronic diseases of internal organs in them.

Methods of administration and dosage

Rebamipide 100 mg (the price of the product depends on its quantity in the package) is taken only orally after a preliminary diagnostic examination by a doctor. Depending on the disease, the therapy regimen may differ.

With gastritis

Depending on the severity of the symptoms, the specialist determines the individual treatment tactics for each patient.

Stage of the disease	Dose and duration of the course
Acute stage	In the acute stage of the pathological condition, patients take the drug 1 tablet 2 times a day. The duration of therapy is 4 weeks. After that, the doctor evaluates the result of the treatment, if necessary, prolongs it or adjusts the dosage.
Subacute or chronic	In the chronic and subacute course of the disease, the drug can be taken 2 tablets per day for 8 weeks. This is the standard course duration for a therapeutic result, but it may vary from patient to patient.

The tablets are taken orally, without chewing, washed down with plenty of water to accelerate the dissolution of the film shell.

With peptic ulcer

When diagnosing a peptic ulcer, the agent is used in courses of 8-10 days. Usually the drug is prescribed in the subacute stage, when acute manifestations are absent and do not aggravate the general condition.

The daily dosage does not exceed 3 tablets, it is divided into 3 doses during the day, while making equal time intervals. Throughout the entire course of treatment, a change in dose is possible, so the patient regularly visits a doctor who assesses his condition.

Only in some cases, the dose can be increased to 400 mg per day, that is, the patient takes 4 tablets of the drug daily, dividing the norm by 4 times. If for any reason the patient missed taking the medication, you should not use a double rate, this can provoke complications.

Side effects

Rebamipide 100 mg (the price of the drug for some patients is an obstacle to use) leads to acute and subacute disorders in the case of improper use. Compliance with the instructions does not guarantee the absence of complications.

Most common reactions:

• On the part of the digestive organs, complications do not occur in every patient, they manifest themselves in the form of nausea and bouts of vomiting, pain in the abdomen. Some patients report a deterioration in appetite, thirst and dryness of the tissues of the oral cavity. Depending on the individual characteristics of the body, complications can manifest themselves in the form of constipation or diarrhea, flatulence and bloating.
• From the side of the central nervous system, negative symptoms usually appear against the background of damage to the digestive system. Patients speak of weakness and severe headache, severe fatigue and sleep disorders. For some time, the symptoms may worsen, which only worsens the state of health.
• Violation of the production of blood cells is observed with prolonged uncontrolled use. Usually, the symptoms do not worsen, they disappear after discontinuation of therapy.
• In women, with prolonged use, menstrual irregularities are observed, especially if there is a history of hormonal disorders.
• Allergy to a medication manifests itself often, in most cases its symptoms are standard, that is, a small rash appears on the body, severe irritation, and peeling. For a short period of time, the rash can cover large areas of the skin, accompanied by severe itching.

Allergic manifestations are observed more often than other reactions. When scratching the affected areas, damage to the outer layer of the skin is noted, which only worsens the condition. Complications may disappear on their own after discontinuation of therapy, but it may be necessary to prescribe drugs to eliminate them.

Overdose

When taking the medicine in doses prescribed by a specialist, an overdose does not develop. But taking a large number of pills on your own can provoke such complications. In this case, the general condition of the patient deteriorates significantly, there is repeated or indomitable vomiting and severe thirst, dryness of the tissues of the oral cavity.

Over the course of several hours, the condition worsens, which leads to the appearance of symptoms from the side of the brain. There is severe weakness, marked disorder of coordination of movements, dizziness and flashing of flies before the eyes. The drug does not lead to significant changes in blood pressure, but some patients with chronic abnormalities report a worsening of their condition.

Overdose is often accompanied by an acute allergic reaction, in which the itching of the skin becomes unbearable, and the rash covers large areas on the body and limbs. Additionally, patients may be disturbed by allergic conjunctivitis, rhinitis, which is accompanied by lacrimation and nasal congestion. The appearance of such manifestations is a reason for an urgent visit to a doctor. This is associated with a threat to the health and even the life of the patient.

In the hospital, the patient is washed the stomach and prescribed means to improve well-being. Most often, enterosorbents, antitoxic drugs, antihistamines are included in the therapy regimen. The treatment is carried out under the supervision of a physician and usually takes no more than 5 days.

special instructions

Rebamipid 100 mg (the price of the drug is lower when purchasing only 1 plate of tablets) is taken only in courses. This is due to the lack of a positive therapeutic effect after taking a single dose of the drug. A pronounced result can be achieved only after completing a full course.

In the first few days after the start of treatment, it is possible to change the consistency and color of feces. Symptoms usually disappear and do not lead to additional complications. In the event of other negative violations, it is worth contacting a specialist.

It is forbidden to independently adjust the dose or change the duration of the course, especially in the case of an acute course of pathology and the presence of concomitant deviations.

Drug interactions

In some cases, the drug is prescribed in combination with antibiotics, non-steroidal anti-inflammatory drugs, vascular and antihypertensive drugs.

Do not take pills with antacids at the same time, as their effectiveness may be weakened. If it becomes necessary to use several medications, you should first visit a doctor.

Experts pay attention to the fact that the use of drugs with similar properties during the period of treatment with tablets is not recommended.

Analogs

If it is impossible to prescribe a remedy for various reasons, doctors select suitable substitutes for patients with similar properties.

Effective analogues:

• Omeprazole contains the active ingredient of the same name in the composition, but has similar therapeutic properties. The drug reduces the acidity of gastric juice, protects the mucous membranes of the stomach from the negative effects of food, drinks and other medicines. The remedy is taken in short courses, unlike the original, it is often prescribed in combination with other pills to increase the effectiveness of treatment.
• Gastrocepin also has gastroprotective properties, helps to restore the mucous membranes of the stomach, reduces the likelihood of disturbances as a result of the progression of gastritis, gastroduodenitis, ulcerative disease. The medicine is produced in tablet form, as well as in the form of a solution intended for parenteral administration. The drug is used even in the presence of acute symptoms from the stomach and intestines.
• Pantoprazole also has pronounced medicinal properties in diagnosing pathologies of the stomach and duodenum. The medication creates a protective film on the mucous membranes, helps to restore damaged areas, and reduces the likelihood of lesions spreading to large areas. The agent is usually administered intravenously, and the course lasts no more than 2 weeks.

The tool has no structural analogues, therefore, doctors in each case take into account the peculiarities of the course of pathology in each patient. Patients on their own cannot use analogues, since each of them has a different composition and has different properties, and can provoke complications.

Storage conditions and periods

The drug may only be stored in a dark and cool place, it is important to protect it from children and exposure to sunlight.

The maximum storage period does not exceed 3 goals. After the expiration of this period of validity is prohibited. Information from the manufacturer is indicated on the packaging, it is worth studying it before using.

Rebamipide 100 mg is an effective remedy for the treatment of gastric pathologies of inflammatory and erosive-ulcerative origin. The drug in tablet form helps to stop the symptoms of diseases and reduces the likelihood of complications. The cost of the drug is high, but it is justified, since most patients note a positive result during the course.

Video about the drug Rebamipid

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